Human Mammary Luminal Epithelial Cells Contain Progenitors to Myoepithelial Cells
نویسندگان
چکیده
منابع مشابه
The mammary epithelium is composed of a luminal epithelium and a basal layer containing myoepithelial cells
In adult females, the mammary epithelium is organized in two layers, a luminal epithelium and a basal layer, consisting of myoepithelial cells. Undifferentiated precursors of both luminal and myoepithelial cells are also believed to be basally localized. The mammary epithelium bilayer is surrounded by a basement membrane embedded in connective tissue. In the fully differentiated mammary gland, ...
متن کاملCharacterization of Human Mammary Epithelial Stem Cells
Previous studies have demonstrated that normal mammary tissue contains a hierarchy of cell types that are ultimately and continuously derived from a self-sustaining mammary stem cell population. However, a suitable assay for detecting, quantifying and characterizing such cells in humans has been lacking. Here we show that histologically normal, bi-layered mammary epithelial structures containin...
متن کاملAge-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells
Luminal epithelial cells in the breast gradually alter gene and protein expression with age, appearing to lose lineage-specificity by acquiring myoepithelial-like characteristics. We hypothesize that the luminal lineage is particularly sensitive to microenvironment changes, and age-related microenvironment changes cause altered luminal cell phenotypes. To evaluate the effects of different micro...
متن کاملEvidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types and express early developmental markers, in contrast to tumors induced by other ...
متن کاملEpithelial cells, Exracellular matrix
چکیده مقدمه: ماده خارج سلولی به عنوان بخش مهم ریز محیطMicroenvironment)(، نقش اساسی در نگهداری وضعیت تمایز دارد. در بررسیهای گذشته، این اثر در برخی سلولها از جمله سلولهای پوششی لوله رحم و یا رحم مطالعه شده است. در این پژوهشها، برای حفظ تمایز سلول ، علاوه بر ماده خارج سلولی عوامل دیگری مانند هورمونها، فاکتورهای رشد و سلولهای داربستی نیز بکار رفته است ولی فر...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 1999
ISSN: 0012-1606
DOI: 10.1006/dbio.1998.9133